Cant speak to Desdemona to warn her. I tried reloading, resaving, restarting, anything. She just wont react. Does not matter if the brotherhood is alive or if I killed everyone on Prydwen, still the same. Has this been addressed? Because I am sitting on my 150+ hours save with everything ready to get the railroad finale and I am stuck.

I had the same problem. I reloaded, to where Bos is still alive.

Is gorly in the railroad still alive? Or Bos old guy brandis?

I wiped out the brotherhood...I guess that is what screwed the game. Guess I will restart then and babysit glory back to the old church. But I do not think that is the solution, other people are stuck as well and Bos and glory are alive.

Brandis. Hes the problem i think

That is weird, because I think I did not help Brandis rejoin in this playtrough...he should be still locked in the old bunker.