» Tue Nov 20, 2012 8:13 pm
Serana and all of her family are of the NordRace, not NordRaceVampire, but she has all the proper keywords to be considered undead and a vampire. They use the glowing vampire eyes (two kinds -- red and "headlight" yellow) by default. In other words, she's a vampire by default.
Whoever you turn into a vampire already had eyes chosen in the Creation Kit, and one cannot update head parts (eyebrows, eyes, hair, etc.) "on the fly" in-game. Further, NPCs require their face data -- mesh and texture -- to be exported into the game's data files. If their in-game face data conflicts with the exported data, their face looses all color and will not match their skin tone.
However, it's possible to change which eye texture is used and thereby create a reasonable facsimilie*: http://steamcommunity.com/profiles/76561198052260730/screenshot/921238949680482380?tab=public
While Serana is a special snowflake by nature of her vampirism, extensively editing a player's spouse (if a follower) would probably provoke an outcry -- for example, Brelyna Maryon (link above), given the Vampiric Drain spell, began to fight actively in combat instead of using her staff and summons.
*Her eyes don't glow; it's a trick of the lighting.