So yeah, this just happened to me.

Video: https://youtu.be/JqJfJhs72Bo

I went to load an Autosave and the whole game crashed. Restarting the game allowed me to load the auto save no problem.

Not sure if it's relevant, but I had the Pip Boy app running on my Android tablet and connected to the game at the time.

I've had this happen a few times. Haven't found out why it happens, normally I just reload or finish the trip. Typically I never even see anything worth shooting during my flight anyways.