Spoiler
make Serana human and not have to make myself a vampire again in order to re-enter the Soul Cairn.
The problem is that, for Skyrim I like to play a good character, as playing a bad character isn't really feasible as almost all your quests outside of the DB questline are "Hero of the day!" type quests. This would mean that he'd wipe out the Dark Brotherhood, which you can do, but he'd also want to purge Riften of the Thieves Guild, which you are never given the option of doing, and you are even forced to do the first quest in the Thieves Guild questline if you don't have really high speech and the persuasion perk.
Bethesda really needs to add the option to drive/wipe out the Thieves Guild, rather than forcing characters to start the questline. Or, at the very least, allow players to complete the Thieves Guild questline without becoming Nightingales, even if that means sacrificing the Guild Master rank (Delvin could take your place as the thiurd Nightingale and Brynjolf could end up leading against his will).
Am I the only one that feels this way about the Thieves Guild faction & questline, and is there any way to get Bethesda to finally pay attention to this issue?