Or are going to try?
One of the best things about dishonored is the complete freedom to choose how to do things. This allows a vast array of specific challenges to set yourself in a playthrough.
Personally, in the past, I've tried a pirate playthrough, using primarily the pistol and sword, with very little respect paid to stealth. This led to high chaos, of course, but otherwise, it was pretty fun.
I might try a "The thing" themed playthrough, focusing on use of possession and lethality. Not sure how well that'll go, though. High mana cost+short amount of time=unviable? We'll see.