Telekenesis. Maybe making singularities. I'd really like to get some souped up version of our standard powers towards the end a la Half Life 2.
That might be a little OP (the HL2 part). By Singularities, do you mean a la Mass Effect? That would be cool, but possibly OP and wouldn't work well with the story and environment.
I think it would be awesome if he had a power that allowed him to interact with his environment in a way that other games don't.
Maybe a power that let him "draw from the deck of many many things" or something to that effect.
If you don't play D&D, the deck of many many things was similar to the wabbajack in Skyrim but way cooler and a lot more things could happen if you used it. Sometimes it would cause irreversable damage, sometimes a gold door would fall from the sky killing your companion but giving you tons of money.... It was way kewl, and you never really knew what was going to happen when you drew from it.
I remember one time I drew from it and I became a female Dwarf named "Janet Thunderthighs" it was awesome.
That would be fun, but a serious game like Dishonored might not have that.