Lockpicking. You don't have to put a single perk in this tree to successfuly pick locks.
Pickpocket is alright. The two top perks are fun and very useful if you can sneak up on your enemy before the fight. Reverse-pickpocketing poisons adds variety to the assassin's profession.
Speech has a few useful merchant perks. Any character benefits from investing in stores, and the fencing perks is great for thieves.
At least lockpicking and pickpocketing have some use in decent perks. Speech doesn't have even that.
Which lockpicking perk is decent? Quick Hands is the only one remotely useful, but you don't really need it if you can sneak.