I'm playing as a Nord Warrior/Hunter type, who is suitably also a werewolf. I use single or dual swords most of the time, with use of bows and daggers for situations where stealth is required.
..and if things go bad, it's time to transform and eat some mofos.
..and let's not forget shouts, I use them a lot now in combat, particularly the 'Marked for Death' shout against dragons, which seems to completely nerf their damage resistance

then just wade in with dual swords and a damage enhancing potion, and it's goodnight in a few swings.