My game never crashed before, the only problem I had was when it would freeze.
But I was playing last night and I was on my way to Novak when I saw some city to the southeast. I started up the Wheel of Fortune quest and went to get the radiation suits. I brought them back and we made our way towards the police station but the NPCs got trashed and they all died. Shortly after I started activating the turrets and Im glad I crashed because I want to start over on that quest anyway. But I was activating turrets at the time and I was wondering if that had something to do with it.
I had also switched from HDR to Bloom and everything was a bit darker at night than usual.

I dunno. I'm guessing it's a quest bug though because I have never had a crash problem before.

Got a DEP crash this time in the same area after loading an older save. Obviously turned off DEP for falloutnv.exe.
I'm wondering if this has something to do with the game autosaving and loading things at the same time?
Also turned HDR back on so that has nothing much to do with it.