At times i kinda wanted to stop doing all my characters the same way, but i always ended up with Agility 10 and Luck 2... The game punished me by giving me crazy critical misses, exploding weapons, knocking myself down, and getting random encounters that were creepy and deadly.
I just worry that if New Vegas is too similar to Fallout 3 then giving yourself 10 Agility will by far outweigh the negative consequences of having a 1 Luck. I don't want to make the game any easier. I'd rather play on Normal with 3 Endurance and 3 Luck (and the resultant points distributed sanely) than play on Very Hard with 10 Agility and 10 Strength....or something.
Actually....maybe some combination of very high Strength, Endurance, Agility, and potentially Luck with very low Intelligence, Charisma, and Perception would be interesting. Granted it would just be a killing machine...but that might make a good first or second run. It would limit how much of the world you got to experience...but it would be an interesting experience.
Would be a good way to prep for Duke Nukem Forever