Unless the game actually freezes, just leave it to load, it will sometimes take a while. You could turn ALL the autosaving options off to decrease the loading time and the amount of freezing, but you would then have to remember to save yourself when you needed to. Make sure you have enough free space on the hard drive, and saving to the hard drive rather than some other place would be best. If you still have problems and you have the space you could install Skyrim to the hard drive if you have no already done so.
As a last resort you could try this suggestion.
If you haven't tried these already, be sure to do the following:
· Clear the system cache
· Delete/reinstall the game data (if installed to HDD)
· Delete/reinstall patches and all DLCs