I've been recently thinking about this and I'm wondering about a couple things.

1. Is it worth it for me to have Broken Steel installed or should I just drop it, also should I Drop Point Lookout too.

2. If I uninstall Broken Steel can I still play Point Lookout and Mothership Zeta or will I need to uninstall both of those.

3. Will the patch (I think it's the latest one) still work if I uninstall these DLC's.

Broken Steel ups your level cap to 30, instead of 20. Also, there is a definite end, without Broken Steel involved. As in credits rolling kinda end. I like Broken Steel, the extra perks were meh, except one for me. Quantum Chemist is really the only perk that I want out of BS. However, I like the quest line (whether my character does it or not, is a different story), there is a lot of heavy combat.....

Point Lookout was the best DLC in my opinion. Yes, better than the Pitt.

I don't know about question #2 or 3, but I believe that any patch will still work.

I'll asnwer 2 and 3 first No you won't need to uninstall PL or MZ if you remove BS all of the dlc are independant and don't rely on one another for anything so you can run any combination you wish, the patch will still work no matter what dlc you have if any again nothing rely's on the dlc so the patch works regardless of any dlc. As for wether it's worth having BS or PL installed thats kinda up tp you I thought both were fairly fun and the only reason I would have to remove them would be for stability and in that case I would cut my least favorite dlc those veing OA and MZ.

I think I'll definitely drop Zeta and I'll think about Point Lookout and Broken Steel.

Have you tried any of these expansions?

If not, I don't know why you'd want to 'drop' them.