Ah, if this is indeed the wrong place to post this, let me know - but I've sought help on the matter elsewhere with little results and was directed here.
I've used Wrye Bash frequently through my modding adventures. Let me copy-paste quote myself actually:
I'll start with the fact I've used Wrye Bash quite often without incident in the past (still version 275), until sometime last night.
Without warning, it suddenly refused to launch. I thought that strange since I hadn't downloaded anything new not related to Oblivion much less so, and much less something that would modify the libraries, affect Python, etc. so why was it suddenly not working?
Well, I decided I'd simply uninstall it, Python, all related files, etc, clear all related registry entries, and then do a fresh reinstall from TESNexus, Wrye Python 03a and then Bash 275. And I did. Went to run Wrye Bash.. and odd enough, it still wouldn't launch. I've even updated it (first to 287 and then to 290) just to see if possibly, that may have some play in the matter - no luck.
I've tried all of the basic solutions, read over the Wrye Bash readme and various related message boards on other users who've had issues with it launching, and nothing's seemingly related.
-I run Win7 x64, but my Oblivion folder is outside of my Program Files, my Mopy folder is in the same directory my Oblivion.exe is, etc..
-I've tried running the launcher with both Python and Pythonw.exe to no avail.
-Obviously I have UAC disabled, and I've things set so I have ownership of all files/run all programs as administrator, although I double checked this of course.
-Already checked for pidfile.tmp. No dice.
..and I have a bug dump of:
Traceback (most recent call last):
File "bash.py", line 153, in 
main()
File "bash.py", line 139, in main
app = basher.BashApp(False)
File "c:\python26\lib\site-packages\wx-2.8-msw-ansi\wx\_core.py", line 7978, i
n __init__
self._BootstrapApp()
File "c:\python26\lib\site-packages\wx-2.8-msw-ansi\wx\_core.py", line 7552, i
n _BootstrapApp
return _core_.PyApp__BootstrapApp(*args, **kwargs)
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\basher.py", l
ine 4584, in OnInit
self.InitData(progress)
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\basher.py", l
ine 4617, in InitData
bosh.modInfos = bosh.ModInfos()
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\bosh.py", lin
e 7966, in __init__
FileInfos.__init__(self,dirs['mods'],ModInfo)
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\bosh.py", lin
e 7646, in __init__
self.bashDir.join('Table.pkl')))
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\bolt.py", lin
e 1025, in __init__
dictFile.load()
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\bosh.py", lin
e 226, in load
result = bolt.PickleDict.load(self)
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\bolt.py", lin
e 822, in load
self.data.update(cPickle.load(ins))
File "C:\Users\Haelstrom Fist\Desktop\Gaming\Other\Oblivion\Mopy\bolt.py", lin
e 521, in __hash__
return hash(self._cs)
AttributeError: _cs
It gets as far as http://haelstrom.net/images/rehost/ModInfos.png with a rapidly list of files I can't even screenshot if I try, then immediately exits. Any suggestions at all are much appreciated as I'm relatively stumped.