So items that you cannot take cannot be grabbed anymore. This means no more triggering/stopping traps by grabbing them (a favorite of mine when playing stealth characters), no more throwing clutter (like cattle bones, etc) out of the way, and since NPCs are alerted by noises in Skyrim, no tossing these items to create a distraction. This seems like a pointless simplification IMO. They've purportedly added thousands of clutter items to the game, and grabbing is a provided function, so why arbitrarily prevent us from grabbing certain items?