After getting my new clothes I did not return to the mayor. I decided to head off and wrap up the side quests before I furthered the main quest. If you do this, or possibly if you leave Wellsprings before you fully advance the main quest you may run into this same bug. You will not be able to enter any zone, including Wellsprings without a crash. After returning to an old save and advancing the main quest I have only had minor issues.
The graphical issues I still face are texture load/pop-in, flashing NPC models and artifacting at certain occasions.
The texture pop-in is still evident under very rapid movement but is fine in most cases. The screen tear was removed by forcing V-Sync via CCC.
The NPC models will flash rapidly between two frames of animation. The most extreme case was the sheriff in Wellsprings flashing between standing and bending over.
The artifacting still occurs when the frame zooms towards an NPC and occasionally I will get a spent shell casing stuck in the air flashing in and out of existence.
The biggest issue here is rampart in the PC gaming world and getting worse. I am extremely frustrated to time and time again spend my money to be a beta tester. Release your games complete. There is no excuse for me to have to come here and report these bugs to you.