For those of us experiencing those random white orbs, apparently this will be addressed in nvidia's next driver update:

http://forums.guru3d.com/showpost.php?p=3742810&postcount=8

Says the game's AA implementation is at fault, not the driver, so the driver will have to work around it

For those who have suggested to turn off AA and force it in the nvidia control panel, this will not work. At least not on ferm 4xx cards. This will only disable AA, although I must say I have personally had zero issues now that AA is disabled and am really enjoying the game

If you can't live without AA though, you'l have to put up with the spots unless you want to turn off HDR. Might wanna try turning off transparency multisampling as well, it still works as it did in FO3 where the edges of objects are dithered and blood is vastly reduced (but the greass and trees look a lot prettier)