I am currently using an Alienware M14x to play Skyrim, and I have played it before for about 22 hours maxed out, so it isn't really a hardware issue as far as I know. But Skyrim works fine like I can go around open stuff and everything, its just that whenever I enter a loading screen, the game just closes. I really dont know how it even happened. I have removed all mods and reinstalled it, yet it still doesnt work. Does anyone know a fix for this problem? I would greatly appreciate it .

Does it have this same issue on a new game with no mods? Just removing a mod and loading the save will not always work and if the save is corrupted by a mod issue, then you can have these problems even without the mods.

And, are you sure you removed all the mods? If you are using Wrye Bash, and if your using mods, you need to, then you need to remove the Installers along with the Mods in Wrye Bash.

Is one of your drives full? Have you verified the Steam Skyrim cache files? Try deleting most of your saved games.