Title says it all. After the main game menu pops up, Im able to navigate the menu by using my keyboard, but the cursor is missing. Upon loading a game, Im unable to do anything. I can't even open the game menu by pressing the Esc key. I tried disabling the texture pack and all mods. Nothing helps.

It might have recreated you SkyrimPrefs.ini file. It did with mine.

Open it, search for [MAIN] and set bGamepadEnable=0