I think the Quarry is somewhat overrated... on my first playthrough I went there with the AMR, ordinary ammo, and headshotted everything from stealth. I did have 100 guns and sneak, but I didn't even know there were such things as a 'deathclaw alfa' and 'mother' etc. until I started searching the bodies.
Although I don't know how it would go with my current character with his 12 or so sneak. Gotta go find out, I guess.
It
is rather overrated- if you're a ranged-weapon specialist of some sort. Not much challenge when they can never reach you up on your clifftop (or in this case crane-top) perch.
Trying it with Melee or Unarmed is a vastly different story, though, since they actually get to attack
you back and can do a metric
crapton of damage with each hit, especially the Alpha and Mother. Even the best Power Armor won't help, as they get bonus damage (it's resistible, but you can't get enough resistance to actually matter) that bumps their output high enough to overload even massive amounts of DT. Personally, I wouldn't even
attempt it with a Melee or Unarmed character unless he/she was perked out and packing a Ballistic Fist (Unarmed) or Thermic Lance (Melee) and a whole pile of chems and healing supplies. Stacked +HP food items could also work if your Survival skill is fairly high, although you need to time their consumption so as to not waste the benefits.