I've noticed a considerable amount of lag when using the direction pad to select a weapon. This is frustrating when in combat and you want to switch weapons on the fly. This was not present in Fallout 3. I even have the perk that is supposed to make you draw your weapons faster. But it's glitchy, sometimes I have to press two and three times to get a weapon selected. Really sloppy stuff.

Also I've noticed that some enemies can become invincible for short periods of time. I can kill A Deathclaw with one punch of my Powerfist. I was attacked by three, I killed the first two immediately, when the third attacked it showed that it had zero health, and I continued to punch it 5-6 times without any results. This has happened with different enemies quite a few times, and other people on PS forums were complaining about the same thing.

I can no longer hold this game in such high praise; my GOTY. I am just trying to get through it now, my enjoyment has turned to frustration and disappointment.