Nice monitor, like yours, is cool. Good headset is a must, in my opinion. This helps drown all sound, other than in-game sound, away from your senses. In-game music is preference, I never turned it off, but maybe I'll give it a try. No interruptions, a bunch of junk food, plenty of skooma, and easy access to the pisser.
Personally, (noob, I know) I always have my laptop next to me, so I understand things like making potions, enchantments, smithing etc. I find myself spending hours just focusing on those things some days.