Wow, three times already? Man, I am still just rummaging around in the wastes just looking for stuff. Like I found the crashed Vertibird and weapon there and other good stuff. I have yet to find anything special regarding armor but I am sure I will. You just went straight through the main quest then right? I just finished speaking to the Kahns as far as the story line goes and am currently running an errand for the Brotherhood. I found them totally by accident too but I was glad to see them since they probably are still necessary for getting to use the power armor but I am not sure since it hasn't come up yet. I am using generalities as I don't want to spoil anything for anyone. I haven't been to the places you (cough) mentioned yet. I love the whole mucking about trying to find good stuff thing almost as much as the main story line. Kindof "dumpsterdiverish". ;O) Anyway, ya I hadn't thought of how big the save file would get saving a bunch of junk. I usually do save guns ans anything that might be a higher ticket item if it is around a 100% repaired so I can sell them for better stuff and rounds. Anyway speaking of playing the game...
This game is very high end. I tried it on my dual core machine, and it crashed a lot. I then gave it a run on the quad core machine with much higher specs, and it is a lot more stable. Still, a number of things can cause it to crash without fail. If you try to 'take all' from something that has a lot of stuff in it, you will invariably crash. Take a few things at a time only. Also, buying stuff from the travelling vendor can trigger a crash. Sometimes its better to just leave them alone.
The NCR story line mission, Ambassador Crocker can go missing and never re-appear. Just quits I guess, and vanishes. This is sort of annoying given you have to report to him again once you have concluded your mission.
It's easy to get stuck in things or to things, so, don't go jumping around piles of rubble or the like, as you may end up caught in them, and have to re-load.
The repeater weapon bug. It works with the Trail Carbine, the Hunting Shotgun and the Cowboy repeater. Basically, either after reloading or when coming out of VATS, these weapons are non-responsive as you are getting your ass kicked by ghouls, scorpions or worse, death claws. After a few seconds, they start working again, but in the non-working phase, you cannot even get back into VATS. The only hope is to run away.
Also, enemies walking through solid objects, scorpions are the worst offenders, they will be under the ground so you can only see their stinger sailing about on the sands like the dorsal fin of a land shark.
I don't want to be hard on the developers, they have spent a lot of time and effort on this game, there is a lot of content. There does need to be a patch which fixes as many of the fundamental flaws as possible.
In terms of inventory management, it might be a good idea to have a 'deck of cards' that you can click on and see what cards you have, rather than keep scrolling scrolling scrolling, keep those doggies scrolling, raw hide...