I, like most, have a very large number of mods installed. I use BOSS and a Bashed Patch.
My biggest Crash Culprit (and I think I've hunted down and killed the rest) is a really P.I.T.A. gameplay-wise.
At a vendor, any vendor, I see Boxes of Surplus Ammo, Jars of Rifle Powder, Boxes of Primers, etc. And the Vendor will say he has 5, 10, 20 or these. But if I buy more than one, the game crashes.
I can buy 1 of them. If I then accept the sale, I will get the items in the box, and all of those boxes will disappear from the vendor's inventory. I can then buy a box of something else, and continue ad nauseum.
Now, I can deal with this, but imagine, if you will being limited to one jar of powder per vendor. Reloading is slow, and a very unreliable way of getting ammo. So I would like to find out who is responsible.
My guess is that a script associated with the various "Box" type items has been changed.
Mod list follows:

?  00 FalloutNV.esm ?  01 DeadMoney.esm ?  02 HonestHearts.esm ?  03 Community Bugfix Compilation Patch.esm ?  04 CBC Dead Money Patch.esm ?  05 ClassicPack.esm ?  06 MercenaryPack.esm ?  07 TribalPack.esm ?  08 CaravanPack.esm ?  09 Advanced Recon Tech.esm ?  0A NVR-Strip.esm ?  0B rePopulated Wasteland.esm ?  0C IWS-Core.esm [Version 1.95] ?  0D AWorldOfPain(Preview).esm ?  0E More Perks.esm ?  0F More Perks for Companions.esm [Version 1.0.0] ?  10 More Perks for Dead Money.esm [Version 1.0.0] ?  11 More Perks for Honest Hearts.esm [Version 1.0.0] ?  12 More Traits.esm [Version 1.0.0] ?  13 Project Nevada - Core.esm ?  14 Project Nevada - Equipment.esm ?  15 FOOK - New Vegas.esm ?  16 FOOK - New Vegas DLCs.esm ?  17 MoMod.esm [Version 3] ?  18 Community Bugfix Compilation Patch.esp ?  19 CBC Dead Money Patch.esp ?  1A CASM.esp ?  1B Better Burned Man.esp ?  1C NVR-NPCs.esp ?  1D NVR_rePopulated Wasteland_Patch.esp ?  1E NVR-SMOTS-Version 10.esp ?  1F SierraMadrev11.esp ?  20 SierraMadrev1.1B.esp ?  21 FOOK - New Vegas.esp ?  22 FOOK - New Vegas DLCs.esp ?  23 PerkEveryLevel.esp ?  24 Project Nevada - Cyberware.esp ?  25 Project Nevada - Rebalance.esp ?  26 Project Nevada - Dead Money SF + Honest Hearts Patch.esp ?  27 NewVegasBounties.esp ?  28 NewVegasBountiesII.esp ?  29 More Perks Update.esp ?  2A More Perks for Companions Update.esp [Version 1.0.4] ?  2B More Perks for Dead Money Update.esp [Version 1.0.4] ?  ++ More Perks for Honest Hearts Update.esp [Version 1.0.2] ?  2C More Traits Update.esp [Version 1.1.0] ?  2D IWS-Core-Patrols.esp [Version 1.95] ?  ++ IWS-Core-Guards.esp [Version 1.95] ?  ++ IWS-Core-Civilians.esp [Version 1.95] ?  ++ IWS-AS-MedSpawns.esp [Version 1.95] ?  2E AWOP-MoMod.esp ?  ++ IWS-MoMod.esp ?  2F populatedcasino.esp ?  30 Weight8000.esp ?  31 Advanced Recon Gear.esp ?  32 Advanced Recon Tech.esp ?  33 Advanced Recon Gear-Locations Doc Mitchell.esp ?  34 QS_Blackwolf_NV_Backpackmod.esp ?  35 Advanced Recon Gear - Project Nevada.esp ?  ++ dressup.esp ?  ++ MiscItemIconsNV.esp ?  36 WeaponModsixpanded.esp ?  37 WMX-FOOKNV CP.esp ?  38 WMX-DeadMoney.esp ?  39 WMX-HonestHearts.esp ?  ++ WMX-FOOKNV-DLCs CP.esp ?  3A WMX-PreOrderPackCaravan.esp ?  3B WMX-PreOrderPackMercenary.esp ?  3C SimpleStreetLights (Extra Lights).esp ?  3D Fellout.esp ?  3E Interior Lighting Overhaul-Realistic Interiors-Full.esp [Version 5.3.2] ?  3F ILO-RI-Dead Money.esp [Version 1.1] ?  40 ILO-RI-Honest Hearts.esp [Version 1.0] ?  41 Bashed Patch, 0.esp ?  42 CassAlcoholAnesthesia.esp ?  43 ED_E upgrades.esp ?  44 ED-E_BuzzKill.esp ?  45 SRDG.esp ?  46 AtomicWranglersixWorkers.esp 

I know the community bugfix patch has a "fix" involving the cases/boxes.