I used Skyrim HD 4k textures just fine, which are much higher resolution than the DLC textures. Unless they are more optimized or something. I of course, removed it before using Bethesda's texture pack and made a clean install. So I don't currently have any mods, besides the dlc.
the HD Pack is 3gb..... it loads in conjunction with the excisting pack and other mods if you have any..
so the amount of data being loaded is that much more.....
it's the combined loading of additional information that exceeds the typicall 32bit limits from the little bit of testing i'm finding.
also if you do not have at least 1gb of dedicated vram... it really does appear that your chances of CTD is quite a bit higher.
I've a 9600GT and a x1900xtx here as well with skyrim loaded. both have 512mb dedicated... however the common factors that determine if the game remains playable or crashes seem to point to one of 2 things.
Running 32bit version of windows.... be it xp/vista/7/windows 8
OR
Running out of Vram... low dedicated physical video memory unable to "hold" the necessary textures that are loaded.
Ugrids plays into this factor as it loads even more information overloading the already saturated memory.....
If you were using a higher ugrids just fine and then now experience a CTD after using hd texture pack.... i'd suggest dropping your ugrids... or disabling the hd pack via the data files option when you launch skyrim.