Sure enough, I've finally caught up with the demons of CTD. I'm running updated FOMM and NVSE per usual. I get to the "Obsidian Entertainment" screen card and promptly crash to desktop with a Windows XP Error Message.

It should be said that I have recently disabled and removed the Grenade Hotkey mod. I updated Unified UI to accommodate this. Grenade Hotkey is simply unnecessary now with Project Nevada.

Here is my load order.
FalloutNV.esm
Ambient Temperature.esm
Inventory Access.esm
Project Nevada - Core.esm
IWS-Core.esm
Military Explansion Program.esm
FNVToolkit.esm
Primary Needs HUD.esm
Readius_NV.esp
ReallyOTS.esp
IIWR 2.1.0.esp
RustTownV1-1.esp
DWM14EBR.esp
DWMk23.esp
DW1911.esp
DWGlockSet.esp
DWM1014.esp
CazadorAudioFix.esp
LibrarianOfTheWastes.esp
Classic Midwestern Power Armor.esp
FlashlightNVSE.esp
pnv.esp
IWS-Core-Patrols.esp
IWS-Core-Civilians.esp
IWS-AS-MedSpawns.esp
IWS-AS-NoInteriorSpawns.esp
populatedcasino.esp
DK Caucasians.esp
PortableCampsite.esp
AEVegas.esp
ASG.esp
better that gun 223.esp
KerberosPanzer.esp
Kerberosweapons.esp
mac10.esp
DWUSP_V18.esp
DWSigP226.esp
Generic Clothing Color Variations.esp
DW_M4A1NoGrip.esp
RHINO45-70_NV.esp
AirForceArmorT57C.esp
MercCharmerClean.esp
courierpowerarmor.esp
Boacombat2glove.esp
ScrapZapGun Readme (1).esp
mossberg500.esp
Road Warrior's Armor.esp
TacticsAPA.esp
Exciters M4 Pack.esp
MysteriouslyShortMagnum.esp
BoltGun.esp
Neckchains.esp
PimpMyScarf_v2.esp
Powered Power Armor.esp
DestructibleMiniNukes.esp
zaty1elimachete-EasyMode.esp
Murdelizer.esp
Project Nevada - Cyberware.esp
Ambient Temperature - PPA.esp
RCSS.esp
PNVRCSScompatibility.esp
Jump Fall Fixer.esp
NewVegasStrip&FreesideMarkers_v2.esp
Destructibles.esp
Depth of View IE Blur.esp
Fellout.esp
ELECTRO-CITY - Highways and Byways.esp
Nevada Skies.esp
Ambient Temperature - Nevada Skies.esp
Color Me Evil - Cass.esp

Total active plugins: 70
Total plugins: 71

Seems like an .ini issue, but as I lack expert experience in the matter, I could be wrong.
Definitely a .ini issue. Disabled all mods and still CTD'd at the exact same point. Any idea how to fix it still from here?

Delete your ini files and let Steam redownload them. That'll revert you to the defaults.