Ive had this problem for a while now, audio and some actions (allmost allways magic spells) are triggering about 10-60 seconds later than they should. This happens on the main menu screen and ingame. The most comon sounds not to trigger are sounds from spells, creatures, dragons, jumping sounds and music. Somtimes all the audio that does not play when it should comes all at once some time after it should.... any help?

Let me guess, you have vsync disabled?

Nope not at all

Weird. I'm having this issue also but only when I have vsync off. Not only is my audio sometimes delayed, but even actions. For example, sometimes when I let go of a drawn bow the arrow won't actually set off until several seconds after I've already released the string.

I haven't seriously had this problem until this morning. Like I'd fire a bow, then maybe 10 seconds later it will play the sound. Then about a minute after that my entire computer shuts down.

Edit: Neither of these have been a problem in the nearly 300 hours of playtime, Skyrim has hardly ever crashed and never shut down my computer. Now it's happening every few minutes.

I have the same problem. It appeared along with frequent stuttering and high FPS loss. I might be wrong, but this is most likely related to save game bloating: http://www.gamesas.com/topic/1363782-major-issue-save-file-bloat/