It would certainly make them more difficult and less predictable - I mean imagine being frozen solid with ice form, or being made weaker with marked for death, or having your attacks interrupted and sent flying with a fus roh dah and not being able to heal until you've gotten up, or not being able to hide behind obstacles because lightning comes down from the sky to strike you and your allies, or the dragon being able to summon dragon priests or draugr to even up the numbers.
I remember reading an interview way back before the release that said that Dragon shouts could be used against the player, but so far the only enemies that do this are the draugr; and they only use Unrelenting Force.
