Not trying to boast here or anything, but I made it to level 34 with a dead-is-dead character without enchanting or alchemy. (master difficulty, deadly dragons mod installed, potions heal over time instead of instantly-mod installed). No problems until that damn one-hit KO archer in the tomb of ysgramor killed him.
If that's true, you're free to boast all what you want

Me, even with an overpowered Shrink enemies spell, that basically leaves them defenseless, I've died tons of times on Master...

(currently lvl 36).
Maybe is the approach of my character, who loves to teleport behind an enemy and crush him. It's a high risk-high reward tactic, but leaves him pretty exposed. Kinda like Vanguards' Biotic Charge power in Mass Effect 2/3.