Try hardened. Many of the changes include higher DRs to various enemies. As well as DTs.
I just installed this one and tested it out in Scorpion Gulch. I allowed myself to get stung once, and my level 28 character was down to 2 bars of health very quickly...and then the anti-venom failed.
This mod may help fit the bill for OP. It certainly won't hurt...err maybe it will. :whistling: