Could be a few things:
1) Make sure the launcher didn't reset your settings and mistakenly ratchet up your settings (it loves to set 8xAA for example any time you touch the presets)
2) Some patches and updates can cause the first cell load to be really hitchy/stuttery after the update. If you can try loading that cell, saving, then loading again to see if its still dropping.
3) Nvidia may have changed their VRAM management algorithms in this driver, if that's the case there may not be too much you can do other than go back to older drivers.