If you have Microsoft Security Essentials Installed, turn off Real Time Protection whilst playing.

Hopefully Bethesda can work something out...

Glad to know this is working. Thanks for the post letting everyone know. Will watch to see how common this solution is to those with this problem.

Honestly though... knowing Micro$oft... I think it is probably more their problem than Bethesda's. If Micro$oft had made this game we would be fighting for compatibility and tweaking just to get INTO THE FORUMS before we even had to post about the game Not to mention have to wait half a year or more till it was ironed down to somewhat reliable... and then release a replacement that should have been a free upgrade later (7 vs Vista). As much as I rag on Bethesda for bugs they have NOTHING on Micro$oft

Thank you very much, this worked for me.