For example, I am using a mod which placed 5 merchant NPCs in Doc Mitchell' house, and a mod which gather all of my companion in Lucky38 room. Whenever I'm either one of these interior, my game become very lag, sometime freeze or even crash.
However if I'm in interior of vanilla game, such as vault 21, It also has a lot of NPC, but I will not experience lag in there.
What is the cause of this issue and how can I solve it?