Ive been fighting with this problem for the last few hours. No matter what the settings are before hand (I play on high) the textures automatically revert to low res and it looks really bad. I havent reinstalled yet but I have moved and unchecked the Hi Res Packs, disabled all mods, deleted Skyrim.ini and reset it by verifying game cache. I really havent done anything that could goof with the textures beforehand. I dont have any shader or texture mods besides the hi res pack supplied by bethesda.
Windows 7 x64
ATI Radeon Mobility HD 3670
Intel Core 2 Duo 2.53 GHz CPU
4GB RAM