I am currently vilified with NCR and the Legion, going the independent/take over everything route. House is dead, Yes Man is in place and I have a Wild Card quest with all optional choices. It lets me pick and choose which sub-factions to ignore.

I've ignored the ones I wanted, but I'm not seeing a way to continue? I'm not able to get Yes Man to give me any other options to move forward in the game. I read in another post that if you ignore/leave alone all the sub-factions, Yes Man will then prompt you with new quest options.

Is that the only way to do it, or am I missing something else? I'd like to move forward with the main questline, but don't mind some of those factions getting obliterated, lol.

Hope that makes sense, thanks for your help.

Iirc you have to checkout all the factions and tell Yes Man what you think of them... after that I recall getting the quest to mess with the El Dorado generator and/or save the president.

Thanks, that helped. Apparently I need to do some quests with each of the factions to sort of "neutralize" their potential threat. Didn't understand that part originally.

Looks like I got some more work ahead of me.