Has anyone gone solo joined no factions. Im thinking i wanna take down the NCR, Ceasers legion and mr house and just probably support the small factions like the kings etc? Do you get any bonuses or disadvantages being a one man army

I am going towards that direction I guess, plus I intentionally not use any companion. Perhaps you may forfeit some quest that can be offered by certain characters from the faction should you kill them. Then again, I suggest to try to get as much EXP or loot or whatever from those faction before going on a faction killing spree.