Do you use the 1.00 version of the Unnoficial Skyrim Patch? If so, I would hold off.
Do you use a lot of mods? There are some animation mods that don't properly function anymore, along with killmoves. Scripts were also recompiled with the 1.6.89 patch, so it can cause a few issues.
Do you really want horse combat? It's a nice option, but the novelty of it wears off quickly.
Were I you, I would postpone updating until the next patch... Or once Dawnguard is released.