Literally the only two things that change when you change the difficulty are the damage taken and the damage you do. That's it.
I wish those were seperate from each other too.
Cos I like dealing slightly less damage, without taking double damage...
I stick to the middle difficulty in all Beth games I play, to keep it an even playing field.
Oh, and with the mods I run, it can be very tough sometimes.
Difficulty slider is useless except for e-ego pumping.