I've been noticing lately that sound effects do not load correctly when going into different areas. For example, you can hear crickets at night when you are outside. However, when you go into a building, the sound continues. Go back outside, same thing. Another example is a place like Freeside where you can hear things in the distance such as broken bottles, screams, talking, etc. Sounds pretty cool. However, if you leave Freeside and wander far into the Mojave Wasteland, you can still hear it. The sound files are not loading correctly. This possibly has always happened and I just didn't notice but lately I've been more attuned to the sound and its getting annoying.
I play on a 360 so any mod/fixes won't work for me. However, this really needs to be patched.
Also, if you save the game, and re-load it, the sound is fixed (at least until you go into a new loading area).