I want to poison Nazeem, i know yu can poison your weapons but how do you literally make people consume it? Do you pickpocket them?

you can put poisons in his inventory via pickpocketing

This

If you have that perk that allows that.

It's called "poisoner" under the pickpocket tree (need 40 pickpocket skill to take it).

There's a perk in the pickpocketting tree that allows you to reverse-pickpocket poisons onto NPC's.

Get a poison apple and.....

Oh wait, nvm.

Why not take credit for killing the new "Adoring Fan" of Skyrim. Everyone may be scared at first, but they will appreciate your ability to do what needs to be done!