Yes, take a break. I found this happening to me about a month after release (despite the fact I had done so little). I took a break and now I'm playing it again and enjoying it.
I've been taking close to 2 1/2 week haitus.. I kept having issues with my textures not scaling back up, kept turning to putty. Fixed it though.. still not High Res but at least I can play the game now (to a point, I take breaks for my eyes every once in a while).
But I started playing yesterday and just kept finding ALL SORTS of quests I never found before.. that's what got me back playing it.. playing it right now lolz.