Honestly ? Didn't you experience game breaking lockups ? I did at only 300 hours.
When did you start this 2000 hour save ? By which I mean what patches did you have downloaded.
I got around them with the console on the PC, there's one, the dreaded aspect of Peryite glitch though. If I disable smaller mods the Aspect of Peryite appears out of nowhere and initiates a locked dialogue. Can't tab out and there are no choices, if you do manage to get out he just initiates conversaiton with you again. But re-enabling the mods made him go away.
edit: I've actually had the save since 11-11-11, got lucky and didn't get anything game breaking that couldn't be fixed with the console besides the aspect.