His immediate guard force will be armed with displacer gloves
Displacer gloves? Ha, I wish! Only Caesar has one; the rest all have ballistic fists, which do 2x the damage.
The easiest way I've found is to use a high-powered gun (which has a short reload time) along with some armor-piercing bullets. This Machine + AP .308 rounds = massive death. If you bring along a companion with one of their optimum weapons, like Veronica equipped with Pushy or a ballistic fist in power armor, killing Caesar becomes a cakewalk.
Personally, I bring along Boone for RP reasons, but you have to keep an eye on him since he requires you to storm the Fort instead of walking right up to Caesar and fighting your way out. He's especially difficult in close quarters, like in Caesar's tent, since he needs to be at medium range to be effective. Giving him a melee weapon that ignores DR, like a chainsaw, and then changing his combat settings from ranged to melee seems to alleviate this problem.
Also: stimpaks. Jet too, if you rely on V.A.T.S. and find yourself in a tight spot.