I can't stand Maven Black-Briar and would really like to end her miserable little life. I know she's too important right now, but is there ever a time when I can snuff her out? I'm not very far in the Thieves' Guild quests, but when I finish those, is she fair game? Also, I know she's involved if you side with the Imperials, but I'm planning to go Stormcloak all the way. (However, I haven't even begun the civil war quests...)

Please, her smug little face really needs to end up in a ditch somewhere!

Unfortunately no. There are a lot of essential NPCs that need to die or suffer in the dungeon of my Dark Brotherhood Dawnstar Sanctuary.