S 6 (if you are planning on 4 STR, add 2 extra points to compensate for Rad Child critical/deadly rad poisoning)
P 5
E 5
C 1
I 8
A 5 (melee doesn't need to use VATS as much)
L 10 (nearly every hit will already be critical; no need for Finesse perk; no need for implant or Intense training)
Implants
STR +1
END +1 (neutral cost; END implant does not use up implant slot because it adds one more slot)
INT +1
AGI +1 (qualify for Silent Running)
PER +1 (qualify for Better Criticals)
Sub-Dermal Armor (+4 DT)
Perk Suggestions
Whiskey Rose (Cass companion perk, provides +2 STR and +4 DT to +6 DT by constantly drinking whiskey; if you take this perk maybe you can put one or two SPECIAL points less into STR)
Super Slam (requires Melee 45; allows you to wipe out large groups of enemies without breaking a sweat)
Rad Child (requires Survival 70; allows you to regen +6HP/sec to +8HP/sec if you stay at critical or deadly rad poisoning, 60-80 times more effective than Monocyte Breeder Implant)
Comprehension (permanent +20 science and permanent +16 each other skill if you find all the skill books; each magazine provides temporary +20 points)
Toughness x 2 ranks (+6 DT)
Stonewall (+5 DT vs. melee, also makes you immune to knockdowns)
Jury Rigger (requires 90 repair, makes repairing armor and super sledge much cheaper)
Piercing Strike(requires Unarmed 70; negates 15 DT on opponents)
Purifier (+50% damage with melee & unarmed vs super mutants, deathclaws, nightstalkers, ghouls)
Silent Running (requires Sneak 60, Agi 6)
Unstoppable Force (requires Melee 90; melee damage breaks through enemy blocks)
Khan Trick (free perk, requires passing Great Khan dialogue check)
Legion Assault (free perk, requires dialogue check with Lucius, 50 unarmed)
Ranger Takedown (free perk, requires dialogue check with Ranger Andy)
Scribe Counter (free perk, requires giving Veronica formalwear)
Meat of Champions (free perk, requires cannibalism and special quest)
Perks to Avoid
Intense Training
Educated (only 15 perks in the game, don't use one up to get a few extra skill points because you can use magazines for +20 points any time you need to reach 100 or pass a high dialogue check)
Here and Now
Monocyte Breeder Implant (useless)
Recommended weapons
Machete, Lead Pipe, Tire Iron (early game)
Rebar Club or Super Sledge (later game)