I'd say Gobi. But only because of completely ridiculous 5x crit multiplier.
Sawyer, where were you with your balancing bat when they were adding 5x multipliers on weapons.
The non-unique Sniper is better than the Gobi Rifle.
Not including the Alien Blaster which is pretty much the best weapon in the entire game..
GUNSThe CZ57 Avenger has the highest DPS in the game.
The AMR has the highest base damage. The non-unique Sniper hits harder however if you have a 100% crit build as it does 124 damage on a crit compared to the AMRs 110 non-crit hit.
ENERGY WEAPONSThe Gattling Laser has the highest DPS with the unique Gauss Rifle having the highest base damage.
MELEEOh Baby! is the best melee weapon on the game in both DPS and damage.
UNARMEDBallistic fist is the best.
EXPLOSIVEFat Man obviously but there are only a very few limited amount of shots for this weapon in the entire game.
Oh Baby! is certainly better than the Ballistic fist and the CZ57 Avenger is better than the Gattling Laser but how close quarters weapons compare to ranged ones depends in the situation, skills, perks, playstyle, etc.