The start of skyrim when alduin "guards what do you see" "it's in the clouds" when he's already landed DERP.

That's always annoyed me. It's right [censored] there!

"Have you been to the cloud district very often? O, what am I saying? Of course you don't"
"I ain't done nothin' "
Just hearing those quotes over and over again made me want to kill these NPC's

I personally despise when the woman screams "DRAGON!" during the execution scene I don't know why...

Anything from Farengar. I hate his voice.

Most guard quotes, the entirety of the beginning sequence, anything Ulfric says... Ermm... Well, M'aiq is just about the only NPC I like listening too... Lol

"You show initiative in seeking me out" Jarl Balgruuf the Greater

I didn't. I was told to come and see you by the person that I've just told you sent me, you ruddy great numpkin

Olafa : "Come to chat with old women, hmm? Do your good deeds for the day."

Me : "No ma'am. I'm not!"