I am having a really odd issue, my mouse has a delayed response when clicking. I am talking about a good 5-6 second delay. Its kind of odd since I ran fallout 3 with no issues.

Is anyone else having this problem? I tried altering my fallout ini with the old mouse acceleration tweaks, but it didnt fix it.

Did you try turning Vsync off?

Yep tried it. Oddly enough, my other mouse works fine. I wonder why my Microsoft sidewinder mouse is the only one with that issue