I bought this game when it came out and the game will quit to desktop when i try and start the game from the main menu. The only way i can play it is if i update the amd video drivers through steam but i have to redo this everytime i reboot my pc, my pc can play any game on the market right now with high settings and has never given me problems before,does anybody have any advice on how to fix it?

I remember some others posting the same "solution".
Try using search function, maybe it turns something up, I unfortunately don't remember much more about it.

Good luck!

bump

How does a clean boot work?

clean boot link:
http://support.microsoft.com/kb/929135

You should post as much info as you can about the issue.
What is the error message / code when new vegas exits?
Do you run mods? How long have you had this issue?

Post a dxdiag. http://www.gamesas.com/index.php?/topic/1122570-how-to-dxdiag/