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So the new patch washes out my screen with yellow light if I enable AA or Anistropic at all (which creates crap graphics at no settings)
Why you no read http://www.gamesas.com/topic/1381885-new-patch-totally-screwed-up-my-game/page__view__findpost__p__20945852 about this? I explained how to fix this issue, assuming you have an AMD card running an older driver.
AND it reverses my mouse buttons
One of the "quirks" of 1.6 that we found in the beta is that on first load, it resets all your keybindings. I assume this would include mouse as well, particularly if you changed the left and right handed attack controls around. You should be able to reset this back to the way you originally had it, however. Can you not do that?