Okay, I threw this into the mod detectives thread, but I didn't really get my hopes up in the first place. As the title suggests, I would really appreciate a mod that disables the respawning of fruits, vegetables and nuts (yes, pepper included) entirely. I'm pretty much clueless when it comes to Fallout modding, but this sounds simple enough (perhaps it's even as simple as altering one single line), so maybe someone nice could get around to doing this in a couple of minutes. If no one does, no biggie, but the constant supply of quality food rather annoys me and, as I feel, takes away from the challenge of hardcoe mode.
Doing that ought to be simple, go into geck, select falloutNv.esm
From there do a search all for cactus. You will come across several form type 'script'. You want to look for the plants you want to alter. Like PrickleyPearCactusScript. Double click on that and it will open up a window with some text. Hunt for :
begin onReset
if State == 1
playgroup Backward 1
set State to 0
setdestroyed 0
endif
Delete that, resave the script, save your new esp file, name it whatever you want.
Downside to the above method is that those plants will never respawn. And if you pick them while using the above method, they will not revert to its unpicked look. A fancier way of doing this would be to add a timer. Something that does not automatically refresh the plant on reset. That way you could have it automatically respawn in a month of in-game time.
Also note, I haven't tested the above method, but it looks solid to me

edit: if above works, then you could do extra searches to edit all the other plants you want.